Skip to content

Joshua Schiffman

Professor of Pediatric Hematology and Oncology and Adjunct Professor of Oncological Sciences

Copy Number, Genomics, Hereditary Cancer, Comparative Oncology



Molecular Biology Program


B.S. Brown University

M.D. Brown University School of Medicine



Dr. Joshua Schiffman is a pediatric hematologist-oncologist at Primary Children's Hospital (PCH) and Huntsman Cancer Institute (HCI) at the University of Utah.  He attended the Brown University School of Medicine, followed by pediatric residency and chief residency at Stanford University School of Medicine.  He completed his fellowship training in Pediatric Hematology-Oncology at Stanford University.  While at Stanford, he began their Pediatric Cancer Genetics Program.  Dr. Schiffman has been on the faculty at the University of Utah since 2008, where he is Professor in Pediatrics and an Adjunct Professor in Oncological Sciences.  He serves as the Medical Director for the High Risk Pediatric Cancer Clinic at the University of Utah, where he cares for children and families with inherited risk for cancer.  Dr. Schiffman also is the Education Director for the Program in Personalized Health, where he oversees the teaching of translational and individualized clinical medicine to physicians and their patients.  Dr. Schiffman's research focuses on the development of pediatric cancer and he runs a translational genomics laboratory to identify which children are at risk for cancer and why.  Dr. Schiffman works closely with epidemiologists, population scientists, and molecular biologists to try to answer this question.  Most recently, Dr. Schiffman has recognized the power of comparative oncology to advance the field of cancer research.  Teaming up with collaborators from across the country, the Schiffman Lab is now actively involved in comparing the genomics and functional biology of different species across the animal kingdom and using this information to generate hypotheses and guide experimental design in cancer research.  Dr. Schiffman holds the inaugural Edward B. Clark, MD Endowed Chair in Pediatric Research.


  1. Jasperson KW, Kohlmann W, Gammon A, Slack H, Buchmann L, Hunt J, Kirchhoff AC, Baskin H, Shaaban A, Schiffman JD. Role of rapid sequence whole-body MRI screening in SDH-associated hereditary paraganglioma families. Fam Cancer. 2014 Jun;13(2):257-65.
  2. Mangum DS, Downie J, Mason CC, Jahromi MS, Joshi D, Rodic V, Müschen M, Meeker N, Trede N, Frazer JK, Zhou Y, Cheng C, Jeha S, Pui CH, Willman CL, Harvey RC, Hunger SP, Yang JJ, Barnette P, Mullighan CG, Miles RR, Schiffman JD. VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia. Leukemia. 2014 Jan;28(1):216-20.
  3. Curtin K, Smith KR, Fraser A, Pimentel R, Kohlmann W, Schiffman JD. Familial risk of childhood cancer and tumors in the Li-Fraumeni spectrum in the Utah Population Database: implications for genetic evaluation in pediatric practice. Int J Cancer. 2013 Nov 15;133(10):2444-53.
  4. Schiffman JD, Geller JI, Mundt E, Means A, Means L, Means V. Update on pediatric cancer predisposition syndromes. Pediatr Blood Cancer. 2013 Aug;60(8):1247-52. Review.
  5. Killian JK, Kim SY, Miettinen M, Smith C, Merino M, Tsokos M, Quezado M, Smith WI Jr, Jahromi MS, Xekouki P, Szarek E, Walker RL, Lasota J, Raffeld M, Klotzle B, Wang Z, Jones L, Zhu Y, Wang Y, Waterfall JJ, O'Sullivan MJ, Bibikova M, Pacak K, Stratakis C, Janeway KA, Schiffman JD, Fan JB, Helman L, Meltzer PS. Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor. Cancer Discov. 2013 Jun;3(6):648-57.
  6. Schiffman JD. Genome-wide analyses of sarcoma: implications for future treatment options. Future Oncol. 2013 Mar;9(3):307-10.
  7. Testa JR, Malkin D, Schiffman JD. Connecting molecular pathways to hereditary cancer risk syndromes. Am Soc Clin Oncol Educ Book. 2013:81-90.
  8. Burningham Z, Hashibe M, Spector L, Schiffman JD. The epidemiology of sarcoma. Clin Sarcoma Res. 2012 Oct 4;2(1):14.
  9. Jahromi MS, Putnam AR, Druzgal C, Wright J, Spraker-Perlman H, Kinsey M, Zhou H, Boucher KM, Randall RL, Jones KB, Lucas D, Rosenberg A, Thomas D, Lessnick SL, Schiffman JD. Molecular inversion probe analysis detects novel copy number alterations in Ewing sarcoma. Cancer Genet. 2012 Jul-Aug;205(7-8):391-404.
  10. Knapke S, Zelley K, Nichols KE, Kohlmann W, Schiffman JD. Identification, Management, and Evaluation of Children with Cancer-Predisposition Syndromes. Am Soc Clin Oncol Educ Book. 2012;32:576-584.
  11. Schiffman JD. Hereditary cancer syndromes: if you look, you will find them. Pediatr Blood Cancer. 2012 Jan;58(1):5-6.
  12. Calvert GT, Randall RL, Jones KB, Cannon-Albright L, Lessnick S, Schiffman JD. At-risk populations for osteosarcoma: the syndromes and beyond. Sarcoma. 2012;2012:152382.
  13. Schiffman JD, Lorimer PD, Rodic V, Jahromi MS, Downie JM, Bayerl MG, Sanmann JN, Althof PA, Sanger WG, Barnette P, Perkins SL, Miles RR. Genome wide copy number analysis of paediatric Burkitt lymphoma using formalin-fixed tissues reveals a subset with gain of chromosome 13q and corresponding miRNA over expression. Br J Haematol. 2011 Nov;155(4):477-86.
  14. Geiersbach KB, Jarboe EA, Jahromi MS, Baker CL, Paxton CN, Tripp SR, Schiffman JD. FOXL2 mutation and large-scale genomic imbalances in adult granulosa cell tumors of the ovary. Cancer Genet. 2011 Nov;204(11):596-602.
  15. Schiffman JD. No child left behind in SDHB testing for paragangliomas and pheochromocytomas. J Clin Oncol. 2011 Nov 1;29(31):4070-2.
  16. Jones KB, Schiffman JD, Kohlmann W, Randall RL, Lessnick SL, Cannon-Albright LA. Complex genotype sarcomas display familial inheritance independent of known cancer predisposition syndromes. Cancer Epidemiol Biomarkers Prev. 2011 May;20(5):751-7.
  17. Jahromi MS, Jones KB, Schiffman JD. Copy Number Alterations and Methylation in Ewing's Sarcoma. Sarcoma. 2011;2011:362173.
  18. Schiffman JD, Wright J. Ewing's Sarcoma and Second Malignancies. Sarcoma. 2011;2011:736841.
  19. Meeker ND, Yang JJ, Schiffman JD. Pharmacogenomics of pediatric acute lymphoblastic leukemia. Expert Opin Pharmacother. 2010 Jul;11(10):1621-32. Review.
  20. Rutter J, Winge DR, Schiffman JD. Succinate dehydrogenase - Assembly, regulation and role in human disease. Mitochondrion. 2010 Jun;10(4):393-401. Review.
  21. Schiffman JD, Hodgson JG, VandenBerg SR, Flaherty P, Polley MY, Yu M, Fisher PG, Rowitch DH, Ford JM, Berger MS, Ji H, Gutmann DH, James CD. Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Cancer Res. 2010 Jan 15;70(2):512-9.
  22. Randall RL, Lessnick SL, Jones KB, Gouw LG, Cummings JE, Cannon-Albright L, Schiffman JD. Is There a Predisposition Gene for Ewing's Sarcoma? J Oncol. 2010;2010:397632.
  23. Schiffman JD, Wang Y, McPherson LA, Welch K, Zhang N, Davis R, Lacayo NJ, Dahl GV, Faham M, Ford JM, Ji HP. Molecular inversion probes reveal patterns of 9p21 deletion and copy number aberrations in childhood leukemia. Cancer Genet Cytogenet. 2009 Aug;193(1):9-18.
Last Updated: 7/8/21