Ben Myers

Assistant Professor of Oncological Sciences and
Adjunct Assistant Professor of Bioengineering and of Biochemistry 

Myers Photo

A.B. Harvard University 

Ph.D. University of California, San Francisco

Research

References

benjamin.myers@hci.utah.edu

Ben Myers' Lab Page

Ben Myers'  PubMed Literature Search

 

Molecular Biology Program

Biological Chemistry Program

Signaling across the membrane in development and cancer: Hedgehog, Wnt,
primary cilium, membrane proteins / lipids, second messengers

Research

In multicellular organisms, cell-cell communication is tightly controlled to ensure proper development and prevent diseases such as cancer. My lab studies a key aspect of this process: how extracellular signals are transmitted across the membrane to the cell interior. ​We are tackling this problem from an interdisciplinary perspective, drawing on membrane biochemistry, cell biology, physiology, embryology, and a range of related approaches.
 
Current research in my lab focuses on:
  1. Biochemical mechanisms of signal transduction in the Hedgehog pathway, a quintessential cell fate specification cascade that controls the development of nearly all of our tissues and organs
  2. The physiology of the primary cilium, a tiny antenna-shaped membrane protrusion critical to Hedgehog signaling as well as a range of related pathways in the nervous, cardiovascular, and musculoskeletal systems
  3. Developing new tools to study how transmembrane signaling affects cellular identity more broadly throughout animal biology
A better understanding of these processes will teach us how cellular identity is specified during development and in post-embryonic tissues. It will also help us to design better therapies for birth defects, cancers, and other diseases.
 

References

  1. Deshpande, I, Liang, J, Hedeen, D, Roberts, K.J., Zhang, Y, Ha, B, Latorraca, N.R., Faust, B, Dror, R.O., Beachy, P.A., Myers, B.R.^, Manglik, A.^ Smoothened Stimulation by Membrane Sterols Drives Hedgehog Pathway Activation. Nature, 2019 Jul 1; https://doi.org/10.1038/s41586-019-1355-4 (^ = corresponding author)
  2. Zhang, Y, Bulkley, DP, Xin, Y, Roberts, KJ, Asarnow, DE, Sharma, A, Myers, B.R., Cho W, Cheng Y, Beachy PA. Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched. Cell, Nov 15;175(5):1352-1364.e14 (2018)
  3. Myers, B. R.*^, Neahring, L.*, Zhang, Y., Roberts, K. R., Beachy, P. A.^. Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium. Proc Nat Acad Sci10.1073/pnas.1717891115 (2017) (* = first author; ^ = corresponding author). pdf
    • Commentary by Blassberg and Briscoe in Dev Cell: pdf
  4. Sweeney, R.T.*, McClary, A.C.*, Myers, B.R.*, Biscocho, J.*, et al. Identification of Recurrent SMO and BRAF Mutations in Ameloblastomas. Nat Gen46(7):722-5 (2014). (* = first author)
  5. Myers, B. R., Sever, N., Chong, Y. C., Kim, J., Belani, J. D., Rychnovsky, S., Bazan, J. F., Beachy, P. A. Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the Smoothened Effector of Signal Response. Dev Cell 26(4):346-57 (2013).
  6. Myers, B. R., Sigal, Y. M., Julius, D. Evolution of Thermal Response Properties in a Cold-Activated TRP Channel. PLoS ONE 4(5): e5741. doi:10.1371/journal.pone.0005741 (2009).
  7. Prober, D. A., Zimmerman, S., Myers, B. R., McDermott, B. M., Caron, S., Rihel, J., Kim, S., Kettleborough, R. N. W., Stemple, D. L., Solnica-Krezel, L., Julius, D., Hudspeth, A. J., Schier, A. F. Zebrafish TRPA1 Channels are Required for Behavioral Responses to Mustard Oil but not for Thermosensation or Mechanosensory Hair Cell Function. J Neurosci 28(40):10102-10 (2008).
  8. Myers, B. R., Saimi, Y., Kung, C., Julius, D. Multiple Unbiased Prospective Screens Identify TRP Channels and their Conserved Gating Elements. J Gen Physiol132(5): 481-6 (2008).
  9. Myers, B. R., Bohlen, C., Julius, D. A Yeast Genetic Screen Reveals a Critical Role for the Pore Helix Domain in TRP Channel Gating. Neuron 58(3):362-73 (2008).
  10. Myers, B. R., Julius. D. TRP Channel Structural Biology: New Roles for an Old Fold. Neuron 54(6):847-50 (2007).
  11. Desai, B. N., Myers, B. R., Schreiber, S. L. FKBP12-rapamycin associated protein associates with mitochondria and senses osmotic stress via an intermediate mitochondrial dysfunction. Proc. Natl. Acad. Sci. USA 99(7):4319-24 (2002).

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Last Updated: 7/8/19