Matthew Miller

Assistant Professor of Biochemistry

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B.A. Carleton College

Ph.D. Massachusetts Institute of Technology

Research

References

matthew.miller@biochem.utah.edu

Matthew P. Miller's Lab Page

Matthew P. Miller's PubMed Literature Search

 

Molecular Biology Program

Biological Chemistry Program

Chromosome Segregation, Cell Division, Microtubules, Cell Biology, Biochemistry, Biophysics

Research

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The accurate segregation of chromosomes during cell division is fundamental to cellular and organismal fitness. Errors in this process are the leading cause of miscarriages and congenital birth defects and are the most prevalent genetic alteration in tumor cells. Despite this, we know very little about why chromosome segregation is so defective in these circumstances. Chromosome segregation is mediated by a highly conserved protein complex, the kinetochore, which physically attaches chromosomes to spindle microtubules to pull the chromosomes apart. Kinetochores are incredible protein machines. They move chromosomes by remaining persistently attached to their constantly changing substrate (i.e. dynamically growing and shrinking microtubule tips). They are also signaling hubs, sensing and halting the cell cycle when they’re improperly attached and self-correcting these improper attachments. Although biologists have been fascinated with this process for over a hundred years, we still do not know how the kinetochore achieves these astonishing feats. Our lab takes an interdisciplinary approach, utilizing in vitro reconstitution-based assays combined with yeast genetics and cell biology to understand the macromolecular machines that carry out the process of chromosome segregation.

For more information please see our lab website at https://www.miller.biochem.utah.edu/research

References

  1. Miller, M. P., Evans, R. K., Zelter, A., Geyer, E. A., Rice, L. M., Davis, T. N., Asbury, C. L., Biggins, S. A Stu2-mediated intrinsic tension-sensing pathway promotes chromosome biorientation in vivo. bioRxiv(2018).
  2. Geyer, E. A., Miller, M. P., Brautigam, C. A, Biggins, S., Rice, L. M., Design principles of a microtubule polymerase eLife2018 Jun 13;7. pii: e34574.
  3. Miller, M. P., Asbury, C. L. & Biggins, S. A TOG Protein Confers Tension Sensitivity to Kinetochore-Microtubule Attachments. Cell 165(6):1428-1439 (2016).
  4. Umbreit, N. T., Miller, M. P., et al. Kinetochores require oligomerization of Dam1 complex to maintain microtubule attachments against tension and promote biorientation. Nat. Commun. 5, 4951 (2014).
  5. Attner, M. A., Miller, M. P., Ee, L.-S., Elkin, S. K. & Amon, A. Polo kinase Cdc5 is a central regulator of meiosis I. Proc. Natl. Acad. Sci. U. S. A. 110(35):14278-83 (2013).
  6. Miller, M. P., Amon, A. & Unal, E. Meiosis I: when chromosomes undergo extreme makeover. Curr. Opin. Cell Biol. 25(6):687-96 (2013).
  7. Miller, M. P.*, Unal, E.*, Brar, G. A. & Amon, A. Meiosis I chromosome segregation is established through regulation of microtubule-kinetochore interactions. eLife 1, e00117 (2012). (*) equal contribution
  8. Miller M.P., Suominen P, Aristidou A, Hause B, Van Hoek P, Asleson Dundon C. Lactic acid-producing yeast cells having nonfunctional l- or d-lactate:ferricytochrome c oxidoreductase cells, United States Patent 8,137,953, Issued March 2012.

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Last Updated: 5/23/19