Anne M. Moon
Professor of Pediactrics, Neurobiology & Anatomy and of Human Genetics
B.S. University of Iowa
M.D./Ph.D. Washington University School of Medicine
Anne Moon's PubMed Literature Search
Research
Research in my laboratory is devoted to understanding the mechanisms of normal and pathologic cardiac, limb and lung development with a focus on the role of Fibroblast Growth Factors, particularly FGF8, and Tbx transcription factors in these processes. We have generated novel mouse models of several human birth defect syndromes, including human 22q11 deletion syndromes such as DiGeorge syndrome, Ulnar-mammary syndrome and congenital arrhythmia syndromes. Our studies are providing new insight into the cellular events and molecular programs that are disrupted in these syndromes. This is allowing us to identify new candidate genes for human malformations that are being tested by our collaborators in Human Genetics. We are dissecting the molecular events that occur in response to FGF signaling in vivo, and also developing the tools necessary to study how a cell integrates complex converging inputs from multiple intercellular signaling pathways in order to generate the developmentally "correct" response in the context of a specific morphogenetic event. We are discovering new functions of the Tbx3 protein in cardiac conduction system and structural development in mice, and how mutations in human TBX3 result in the complex features of Ulnar-mammary syndromet.
Congenital heart defects (CHD) are the most common human birth defect:
40,000 affected infants born in the US/year
Twice as many children die/year from CHD than all pediatric cancers combined
References
1. Znosko WA, Yu S, Thomas K, Molina GA, Li C, Tsang W, Dawid IB, Moon AM, Tsang M (2010) Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development. Developmental Biology 342(1):11-25
2. Watanabe Y, Miyagawa-Tomita S, Vincent SD, Kelly RG, Moon AM, Buckingham ME (2010) Role of Mesodermal FGF8 and FGF10 Overlaps in the Development of the Arterial Pole of the Heart and Pharyngeal Arch Arteries. Circulation Research 106(3):495-503
3. Lania G, Zhang Z, Huynh T, Caprio C, Moon AM, Vitelli F, Baldini A (2009) Early thyroid development requires a Tbx1-Fgf8 pathway. Developmental Biology 328 (1):109-117
4. Park EJ, Watanabe Y, Smyth G, Miyagawa-Tomita S, Meyers E, Klingensmith J, Camenisch T, Buckingham M, Moon AM (2008) An FGF autocrine loop, initiated in second heart field mesoderm, regulates morphogenesis at the arterial pole of the heart. Development 135(21):3599-610
5. Park EJ, Sun X, Nichol P, Saijoh Y, Martin JF, Moon AM (2008) A System for Tamoxifen-Inducible Expression of Cre-recombinase from the Foxa2 locus in Mice. Developmental Dynamics Feb;237(2):447-53
6. Hauri-Hohl MM, Zuklys S, Keller MP, Jeker LT, Barthlott T, Moon AM, Roes J, Hollander GA (2008) TGFb signaling in thymic epithelial cells regulates thymic involution and post-irradiation reconstitution. Blood 112(3):626-634
7. Moon AM (2008) Mouse models of congenital cardiovascular disease. Current Topics in Developmental Biology Vol.84:172-206
8. Zhang J, Lin Y, Zhang Y, Lan Y, Lin C, Moon AM, Schwartz RJ, Martin JF, Wang F (2008) Frs2a-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development 135(21):3611-22
9. Park EJ, Sun X, Nichol P, Saijoh Y, Martin JF, Moon AM (2008) A System for Tamoxifen-Inducible Expression of Cre-recombinase from the Foxa2 locus in Mice. Dev Dyn. Feb 237(2):447-53
10. Frank DU, Elliot SA, Park EJ, Hammond J, Saijoh Y, Moon AM (2007) System for Inducible expression of Cre recombines from the Foxa2 locus in endoderm, notochord and floorplate. Developmental Dynamics 15;236(4):1085-1092
11. Haraguchi R, Motoyama J, Sasaki H, Satoh Y, Miyagawa S, Nakagata N, Moon A, Yamada G (2007) Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling. Development 134 525-533
12. Park EJ, Ogden LA, Talbot A, Evans S, Cai C, Black BL, Frank DU, Moon AM (2006) Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development 133:2419-2433
13. Moon AM (2006) Mouse models for investigating the developmental bases of human birth defects. Pediatric Research Jun;59(6):749-55
14. Moon AM, Guris DL, Seo J-H, Li L, Talbot A, Hammond J, Imamoto A (2006) Crkl deficiency disrupts Fgf8 signaling in the pathogenesis of 22q11 deletion syndromes. Developmental Cell 10(1):71-80
15. Boulet AM, Moon AM, Arenkiel B, Capecchi MR (2004) The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth. Dev Biol. 273(2):361-72
16. Macatee TL, Hammond BP, Arenkiel BR, Francis LK, Frank DU, Moon AM (2003) FGF8 performs domain-specific functions during cardiovascular and pharyngeal development. Development 130:6361-6374
17. Frank DF, Fotheringham LK, Brewer JA, Muglia LJ, Tristani-Firouzi M, Capecchi MR, Moon AM (2002) An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. Development 129 (19):4591-603
18. Moon AM, Capecchi MR (2000) FGF8 is required for outgrowth and patterning of the limb. Nature Genetics 26:455-459
Updated 6/1/2011
