Anne Moon
Associate Professor of Neurobiology and Anatomy and of pediatrics
B.S. University of Iowa
M.D./Ph.D. Washington University School of Medicine
Research
My laboratory is devoted to understanding the mechanisms of cardiac, lung and limb development with a focus on the role of Fibroblast Growth Factors and Tbx transcription factors in these processes. We use gene targeting and conditional mutagenesis in mice to create specific genetic alterations at particular stages and locations during embryogenesis and have thus created mouse models of human deletion 22q11 syndromes (cardiac, craniofacial, immunological defects), congenital lethal lung dysplasia, and Ulnar-mammary syndrome. These models permit us to study the cellular and molecular programs that regulate normal and abnormal organogenesis. We are also developing the tools necessary to perform in vivo biochemistry to study how cells integrate complex inputs that converge from multiple intra- and intercellular signaling pathways and subsequently generate the developmentally “correct” response.
References
1. Frank DU, Elliot SA, Park EJ, Hammond J, Saijoh Y, Moon AM (2007) A System for Inducible expression of Cre recombinase from the Foxa2 locus in endoderm, notochord and floorplate. Developmental Dynamics 15;236(4):1085-1092
2. Haraguchi R, Motoyama J, Sasaki H, Satoh Y, Miyagawa S, Nakagata N, Moon A, Yamada G (2007) Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling. Development 134:525-533
3. Park EJ, Ogden LA, Talbot A, Evans S, Cai C, Black BL, Frank DU, Moon AM (2006) Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development 133(12):2419-33
4. Moon AM (2006) Mouse models for investigating the developmental bases of human birth defects. Pediatric Research 59(6):749-55
5. Moon AM, Guris DL, Li L, Hammond J, Imamoto A (2006) Crkl deficiency disrupts Fgf8 signaling in the pathogenesis of 22q11 deletion syndromes. Developmental Cell 10(1):71-80
6. Ladher RK, Wright TJ, Moon AM, Mansour SL, Schoenwolf GC (2005) Initiating inner ear induction: a role for FGF8 in mouse and chick otic development. Genes Dev. Mar 1;19(5):603-13
7. Boulet AM, Moon AM, Arenkiel B, Capecchi MR (2004) The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth. Dev Biol. 273(2):361-72
8. Macatee TL, Hammond BP, Arenkiel BR, Francis L, Frank DU, Moon AM (2003) FGF8 performs domain-specific functions during cardiovascular and pharyngeal development. Development 130:6361-6374
9. Frank DU, Fotheringham LK, Brewer JA, Muglia LJ, Tristani-Firouzi M, Capecchi MR, Moon AM (2002) An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. Development 129 (19):4591-603
