Lynn Jorde
Professor and Chair of Human Genetics
B.A. University of New Mexico
Ph.D. University of New Mexico
Lynn Jorde's PubMed Literature Search
Research
Our laboratory has long been involved in studies of human genetic variation and disease. We have been involved in studies of human limb malformations, autism, hypertension, juvenile idiopathic arthritis, type 2 diabetes, schizophrenia, and a number of other Mendelian and common, complex diseases. For more than a decade, we have been involved in research on the evolution of mobile elements and the effects of these elements on the human genome. We have been actively engaged in studies of natural selection in humans, having recently identified genes involved in high-altitude adaptation. We have used whole-genome sequencing to uncover disease-causing mutations and to estimate the human mutation rate.
References
1. Huff C, Witherspoon D, Simonson T, Xing J, Watkins S, Zhang Y, Tuohy T, Neklason D, Burt R, Guthery S, Woodward S, Jorde LB (2011) Maximum-likelihood estimation of recent shared ancestry (ERSA). Genome Res. (recently published)
2. Batini C, Lopes J, Behar DM, Calafell F, Jorde LB, van der Veen L, Quintana-Murci L, Spedini G, Destro-Bisol G, and Comas D (2011) Insights into the demographic history of African Pygmies from complete mitochondrial genomes. Mol Biol Evol 28(2):1099-1110
3. Xing J, Watkins WS, Hu Y, Huff CD, Sabo A, Muzny DM, Bamshad MJ, Gibbs RA, Jorde LB, Yu F (2010) Genetic diversity in India and the inference of Eurasian population expansion. Genome Biol 11(11):R113.
4. The 1000 Genomes Project Consortium. (2010) Diversity of human copy number variation and multicopy genes. Science 330(6004):641-646.
5. The 1000 Genomes Project Consortium (2010) A map of human genome variation from population scale sequencing. Nature 467(7319):1061-1073
6. Xing J, Watkins WS, Shlien A, Walker e, Huff CD, Witherspoon DJ, Zhang Y, Simonson TS, Weiss RB, Schiffman JD, Malkin D, Woodward SR, Jorde LB (2010) Toward a more Uniform Sampling of Human Genetic Diversity: A Survey of Worldwide Populations by High-density Genotyping. Genomics 96: 199-210
7. Witherspoon DJ, Xing J, Zhang Y, Watkins WS, Batzer MA, Jorde LB (2010) Mobile element scanning (ME-Scan) by targeted high-throughput sequencing. BMC Genomics 11:410
8. Rotimi CN, Jorde LB (2010) Health disparities in the age of genomic medicine. N Engl J Med 363: 1551-7
9. Simonson TS, Yang Y, Huff CD, Yun H, Qin G, Witherspoon DJ, Bai Z, Lorenzo FR, Xing J, Jorde LB*, Prchal JT, Ge R (2010) Genetic evidence for high-altitude adaptation in Tibet. Science 329: 72-75 (*co-senior author)
10. Watkins WS, Rohrwasser A, Peiffer A, Leppert MF, Lalouel JM, Jorde LB (2010) AGT Genetic Variation, Plasma AGT, and Blood Pressure: An Analysis of the Utah Genetic Reference Project Pedigrees. Am J Hypertens 23: 917-23
11. Roach JC, Glusman G, Smit AFA, Huff CD, Hubley R, Shannon PT, Rowen L, Pant KP, Goodman N, Bamshad M, Shendure J, Drmanac R, Jorde LB, Hood L, Galas DJ (2010) Analysis of genetic inheritance in a family quartet by whole-genome sequencing. Science328:636-9
12. Huff CD, Xing J, Rogers AR, Witherspoon DJ, Jorde LB (2010) Mobile elements reveal small population size in the ancient ancestors of Homo sapiens. Proc Natl Acad Sci USA 107: 2147-52
13. Simonson TS, Zhang Y, Huff CD, Xing J, Watkins WS, Witherspoon DJ, Woodward SR, Jorde LB (2010) Limited distribution of a cardiomyopathy-associated variant in India. Ann Hum Genet 74: 184-8
14. Watkins WS, Hunt SC, Williams GH, Tolpinrud W, Jeunemaitre X, Lalouel JM, Jorde LB (2010) Genotype-phenotype analysis of angiotensinogen polymorphisms and essential hypertension: the importance of haplotypes. J Hypertension 28: 65-75
15. Witherspoon DJ, Watkins WS, Zhang Y, Xing J, Tolpinrud WL, Hedges DJ, Batzer MA, Jorde LB (2009) Alu repeats increase local recombination rates. BMC Genomics 10:530
16. Xing J, Zhang Y, Han K, Salem AH, Sen SK, Huff CD, Zhou Q, Kirkness EF, Levy S, Batzer MA, Jorde LB (2009) Mobile elements create structural variation: analysis of a complete human genome. Genome Res 19: 1516-26
17. Xing J, Watkins WS, Witherspoon DJ, Zhang Y, Guthery SL, Thara R, Mowry BJ, Bulayeva K, Weiss RB, Jorde LB (2009) Fine-scaled human genetic structure revealed by SNP microarrays. Genome Res 19(5):815-25
18. Marchani EE, Xing J, Witherspoon DJ, Jorde LB, Rogers AR (2009) Estimating the age of retrotransposon subfamilies using maximum likelihood. Genomics 94: 78-82
Updated 6/1/2011
