Lynn Jorde
Professor of Human Genetics
B.A. University of New Mexico
Ph.D. University of New Mexico
Research
My laboratory is involved in two major areas of research: gene mapping and evolutionary genetics. We are analyzing variation in genes in the renin-angiotensin pathway in a series of Utah families and in a cohort of hypertensive subjects to better understand the role of these genes in hypertension susceptibility. We are also involved in studies of the genetics of schizophrenia, polycythemia, juvenile idiopathic arthritis, and inflammatory bowel disease. Our evolutionary genetic research involves the analysis of worldwide genetic variation in human mitochondrial and nuclear DNA (including the Y chromosome). We have been focusing especially on mobile elements, such as Alu and L1 insertion polymorphisms. We are using these data to test a variety of evolutionary hypotheses, and we are investigating the impact of mobile elements on processes such as recombination and linkage disequilibrium. We have been exploring the implications of population genetic data for current questions about the relevance of “race” in biomedical settings.
References
1. Tong Z, Yang Z, Patel S, Jorde LB, Li DY, Aiello LP, Pollak MR, Zhang K (2008) Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. PNAS 105(19):6998-7003
2. Xing J, Witherspoon DJ, Watkins WS, Zhang Y, Tolpinrud W, Jorde LB (2008) HapMap tagSNP transferability in multiple populations: general guidelines. Genomics 92(1):41-51
3. Xing J, Witherspoon DJ, Ray DA, Batzer MA, Jorde LB (2007) Mobile DNA elements in primate and human evolution. Yearb Phys Anthrop 50:2-19
4. Witherspoon DJ, Wooding S, Rogers AR, Marchani EE, Watkins WS, Batzer MA, Jorde LB (2007) Genetic Similarities Within and Between Human Populations. Genetics 176(1):351-9
5. Rogers AR, Wooding S, Huff CD, Batzer MA, Jorde LB (2007) Ancestral alleles and population origins: inferences depend on mutation rate. Mol Biol Evol 24(4):990-7
6. Toydemir RM, Chen H, Proud VK, Martin R, van Bokhoven H, Hamel BC, Tuerlings JH, Stratakis CA, Jorde LB, Bamshad MJ (2006) Trismus-pseudocamptodactyly syndrome is caused by recurrent mutation of MYH8. Am J Med Genet A 140:2387-2393
7. Toydemir RM, Brassington AE, Bayrak-Toydemir P, Krakowiak PA, Jorde LB, Whitby FG, Longo N, Viskochil DH, Carey JC, Bamshad MJ (2006) A Novel Mutation in FGFR3 Causes Camptodactyly, Tall Stature, and Hearing Loss (CATSHL) Syndrome. Am J Hum Genet 79:935-941
8. Witherspoon DJ, Marchani EE, Watkins WS, Ostler CT, Wooding SP, Anders BA, Fowlkes JD, Boissinot S, Furano AV, Ray DA, Rogers AR, Batzer MA, Jorde LB (2006) Human Population Genetic Structure and Diversity Inferred from Polymorphic L1(LINE-1) and Alu Insertions. Hum Hered 62:30-46
9. Prahalad S, Bohnsack JF, Jorde LB, Whiting A, Clifford B, Dunn D, Weiss R, Moroldo M, Thompson SD, Glass DN, Bamshad MJ (2006) Association of two functional polymorphisms in the CCR5 gene with juvenile rheumatoid arthritis. Genes Immun 7:468-75
10. Kim UK, Wooding S, Riaz N, Jorde LB, Drayna D (2006) Variation in the Human TAS1R Taste Receptor Genes. Chem Senses 31:599-611
11. Toydemir RM, Rutherford A, Whitby FG, Jorde LB, Carey JC, Bamshad MJ (2006) Mutations in embryonic myosin heavy chain (MYH3) cause Freeman-Sheldon syndrome and Sheldon-Hall syndrome. Nature Genet. 38:561-5
12. Wooding S, Jorde LB (2006) Duplication and divergence in humans and chimpanzees. Bioessays 28:335-338
13. Hedges DL, Cordaux R, Xing J, Witherspoon DJ, Rogers AR, Jorde LB, Batzer MA (2005) Modeling the amplification dynamics of Human Alu retrotransposons. PLoS Computational Biology 1:333-340
14. Kim U, Wooding S, Ricci D, Jorde LB, Drayna D (2005) Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci. Hum Mutat 26:199-204
15. Shriver MD, Mei R, Parra EJ, Sonpar V, Halder I, Tishkoff SA, Schurr TG, Zhadanov SI, Osipova LP, Brutsaert TD, Friedlaender J, Jorde LB, Watkins WS, Bamshad MJ, Gutierrez G, Loi H, Matsuzaki H, Kittles RA, Argyropoulos G, Fernandez JR, Akey JM, Jones KW (2005) Large-scale SNP analysis reveals clustered and continuous patterns of human genetic variation. Hum Genomics 2:81-89
16. Nakajima T, Wooding S, Satta Y, Jinnai N, Goto S, Hayasaka I, Saitou N, Guan-Jun J, Tokunaga K, Jorde LB, Emi M, Inoue I (2005) Evidence for natural selection in the HAVCR1 gene: high degree of amino-acid variability in the mucin domain of human HAVCR1 protein. Genes Immun 6:398-406
17. Watkins WS, Prasad BVR, Naidu JM, Rao BB, Bhanu BB, Ramachandran B, Das PK, Gai PB, Reddy PC, Reddy PG, Sethuraman M, Bamshad MJ, Jorde LB (2005) Diversity and divergence among the tribal populations of India. Ann Hum Genet 69:680-92
