Sandra Hasstedt
Associate Professor of Human Genetics
B.S. Colorado State University, Fort Collins
Ph.D. University of Michigan, Ann Arbor
Sandra Hasstedt's Lab Page
Sandra Hasstedt's PubMed Literature Search
Research
My interests lie in the development and application of methodology for the statistical analysis of genetic diseases in families. The goal of the analysis may be to localize the disease gene in the genome or to test variants in candidate genes for disease association. I am interested in three aspects: 1) developing statistical methodology, 2) computerization of the methodology, and 3) analysis of family data using the methodology. I develop and computerize new methodology through modification of PAP (Pedigree Analysis Package), a software package I have written for the analysis of family data. I am currently applying the methodology to finding genes for type 2 diabetes, venous thrombosis, obesity, hypertension, coronary heart disease, and aging.
References
1. Hasstedt SJ, Chu WS, Das SK, Wang H, Elbein SC (2008) Type 2 diabetes susceptibility genes on chromosome 1q21-24. Ann Hum Genet 72:163-9
2. Hasstedt SJ, Scott BT, Rosendaal FR, Callas PW, Vossen CY, Long GL, Bovill EG (2007) Exclusion of the alpha2 subunit of platelet-activating factor acetylhdrolase 1b (PAFAH2B2) as a prothrombotic gene in a protein C-deficient kindred and population-based case-control sample. Thromb Haemost 98:587-92
3. Hunt SC, Xin Y, Wu LL, Cawthon RM, Coon H, Hasstedt SJ, Hopkins PN (2006) Sodium bicarbonate cotransporter polymorphisms are associated with baseline and 10-year follow-up blood pressures. Hypertension 47:532-6
4. Malhotra A, Cromer K, Leppert MF, Hasstedt SJ (2005) The power to detect genetic linkage for quantitative traits in the Utah CEPH pedigrees. J Hum Genet 50:69-75
5. Hasstedt SJ, Camp NJ, Hopkins PN, Coon H, McKinney JT, Cawthon RM, Hunt SC (2004) Model-fitting and linkage analysis of sodium-lithium countertransport. Eur J Hum Genet 12:1055-61
6. Hasstedt SJ, Scott BT, Callas PW, Vossen CY, Rosendaal FR, Long GL, Bovill EG (2004) Genome scan of venous thrombosis in a pedigree with protein C deficiency. J Thromb Haemost 2:868-73
7. Hunt SC, Coon H, Hasstedt SJ, Cawthon RM, Camp NJ, Wu LL, Hopkins PN (2004) Linkage of serum creatinine and glomerular filtration rate to chromosome 2 in Utah pedigrees. Am J Hypertens 17:511-5
Updated 6/13/2011
