Sandra Hasstedt
Associate Professor of Human Genetics
B.S. Colorado State University, Fort Collins
Ph.D. University of Michigan, Ann Arbor
Research
My interests lie in the development and application of methodology for the statistical analysis of genetic diseases in families. The goal of the analysis may be to determine how the disease is inherited or the location of the disease gene in the genome. I am interested in three aspects: 1) developing statistical methodology, 2) computerization of the methodology, and 3) analysis of family data using the methodology. I develop and computerize new methodology through modification of PAP (Pedigree Analysis Package), a software package a have written for the analysis of family data. I am currently applying the methodology to finding the genes for venous thrombosis, aging, and type 2 diabetes.
References
1. Vossen CY, Hasstedt SJ, Scott BT, Rosendaal FR, Bovill EG (2006) A genome search for genetic determinants of markers of protein C activation. J Thromb Haemost 4:706-708
2. Hunt SC, Xin Y, Wu LL, Cawthon RM, Coon H, Hasstedt SJ, Hopkins PN (2006) Sodium bicarbonate cotransporter polymorphisms are associated with baseline and 10-year follow-up blood pressures. Hypertension 47:532-536
3. Coon H, Xin Y, Hopkins PN, Cawthon RM, Hasstedt SJ, Hunt SC (2005) Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides. Hum Genet 117:444-451
4. Malhotra A, Cromer K, Leppert MF, Hasstedt SJ (2005) The power to detect linkage for quantitative traits in the Utah CEPH pedigrees. J Hum Genet 50:69-75
5. Das SK, Chu W, Zhang Z, Hasstedt SJ, Elbein SC (2004) Calsequestrin 1 (CASQ1) gene polymorphisms under chromosome 1q21 peak are associated with type 2 diabetes in Northern European Caucasians. Diabetes 53:3300-3306
6. Hasstedt SJ, Camp NJ, Hopkins PN, Coon H, McKinney JT, Cawthon RM, Hunt SC (2004) Model fitting and linkage analysis of sodium-lithium countertransport. Eur J Hum Genet 12:1055-1061
7. Hunt SC, Coon H, Hasstedt SJ, Cawthon RM, Camp NJ, Wu LL, Hopkins PN (2004) Linkage of serum creatinine and glomerular filtration rate to chromosome 2 in Utah pedigrees. Am J Hypertens 17:511-515
8. Hasstedt SJ, Scott BT, Callas PW, Rosendaal FR, Long GL, Bovill EG (2004) Genome scan of venous thrombosis in a pedigree with protein C deficiency. J Thromb Haemost 2:868-873
9. Vossen CY, Hasstedt SJ, Rosendaal FR, Callas PW, Bauer KA, Broze GJ, Hoogendoorn H, Long GL, Scott BT, Bovill EG (2004) Heritability of plasma concentrations of clotting factors and measures of a prethrombotic state in a protein C-deficient family. J Throm Haemost 2:242-247
10. Das SK, Hasstedt SJ, Zhang Z, Elbein SC (2004) Linkage and association mapping of a chromosome 1q21-q24 type 2 diabetes susceptibility locus in northern European Caucasians. Diabetes 53:492-499
11. Camp NJ, Hopkins PN, Hasstedt SJ, Coon H, Malhotra A, Cawthon RM, Hunt SC (2003) Genome-wide multipoint parametric linkage analysis of pulse pressure in large, extended Utah pedigrees. Hypertension 42:322-328
12. Malhotra A, Peiffer AP, Ryujin DT, Elsner T, Kanner RE, Leppert MF, Hasstedt SJ (2003) Further evidence for a role of genes on chromosome 2 and chromosome 5 in the inheritance of pulmonary function. Am J Respir Crit Care Med 168:556-561
13. Elbein SC, Hasstedt SJ (2002) Quantitative trait linkage analysis of lipid-related traits in familial type 2 diabetes. Evidence for linkage of triglyceride levels to chromosome 19q. Diabetes 51:528-535
14. Hunt SC, Hasstedt SJ, Coon H, Camp NJ, Cawthon RM, Wu LL, Hopkins PN (2002) Linkage of creatinine clearance to chromosome 10 in Utah pedigrees replicates a locus for end-stage renal disease in humans and renal failure in the fawn-hooded rat. Kidney Int 62:1143-1148
