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Scott W. Rogers

Professor of Neurobiology and Anatomy

Scott Rogers

B.S. Utah State University

Ph.D. University of Utah

Research

References

scott.rogers@hsc.utah.edu

Scott Rogers' Lab Page

Scott Rogers' PubMed Literature Search

 

Molecular Biology Program

Neurobiology

Research

Interactions among genetics and the environment shape our developmental processes and ultimately the quality of our life.  My research is focused upon determining the role of nicotinic receptors in cellular processes occurring during development and how altering the expression of these receptors influences developmental outcomes such as the predisposition towards successful aging. Nicotinic receptors are ligand gated ion channels that modulate neuronal function and signal our susceptibility to nicotine addiction.  However, if defective, these receptors contribute to the susceptibility and subsequent etiology of many diseases whose severity can exhibit remarkable variability.  This is also true in the mouse model where mice of different genetic backgrounds exhibit highly varied responses to environmental challenges as well as very different courses in their disease response.  Thus, the mouse offers an excellent model system to examine similar deficiencies in humans.  We are using this genetic approach, combined with methods of homologous recombination, to modify the function of individual nicotinic receptors in precise ways that offer us the ability to study the interactive mechanisms between this receptor system and the environment during pre-natal and early post-natal development. We can then assess how individual receptors and key environmental modulators combine to create outcomes whose importance may not be realized until much later in the individual's life.

References

  1. Rogers SW, Gahring LC (2012) Nicotinic Receptor Alpha7 Expression During Tooth Morphogenesis Reveals Functional Pleiotropy. PlosOne, 7(5):e36467
  2. Rogers SW, Tvrdik P, Capecchi MR, Gahring LC, Rogers SW (2012) Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure. Am J Med Genet A, 158A(5):1135-1144
  3. Gahring LC, Rogers SW (2010) Nicotinic receptor subunit alpha5 modifies assembly, up-regulation, and response to pro-inflammatory cytokines. J Biol Chem, 85(34):26049-26057
  4. Gahring LC, Vasquez-Opazo GA, Rogers SW (2010) Choline promotes nicotinic receptor alpha4+beta2  upregulation. J Biol Chem, 285(26):19793-19801
  5. Weiss RB, Baker TB, Cannon DS, von Niederhausern A, Dunn DM, Matsunami N, Singh NA, Baird L, Coon H, McMahon WM, Piper ME, Fiore MC, Scholand MB, Connett JE, Kanner RE, Gahring LC, Rogers SW, Hoidal JR, Leppert MF (2008) A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS Genet, 4(7):e1000125
  6. Gahring LC, Osborne-Hereford AV, Vasquez-Opazo GA, Rogers, SW (2008) Tumor necrosis factor alpha enhances nicotinic receptor up-regulation via a p38MAPK-dependent pathway. J Biological Chemistry, 283(2):693-699
  7. Weiss RB, Baker TB, Cannon DS, et al (2008) A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS Genet, 4(7):e1000125
  8. Gahring, LC, & Rogers, SW (2008) Nicotinic Acetylcholine Receptor Expression in the Hippocampus of 27 Mouse Strains Reveals Novel Inhibitory Circuitry. Hippocampus, 18(8):737-749
  9. Rogers SW, Weis JJ, Ma Y, Teuscher C, Gahring LC (2008) Mouse Chromosome 11 Harbors Genetic Determinants of Hippocampal Strain-Specific Nicotinic Receptor Expression. Hippocampus, 18(8):750-757

Reviews

  1. Rogers SW, Baker T, Gould TJ (2009) Chapter 3: Mouse Models and the Genetics of Nicotine Addiction. In:National Cancer Institute. Phenotypes and Endophenotypes: Foundations for Genetic Studies of Nicotine Use and Dependence. Tobacco Control Monograph No. 20. Bethesda, MD: U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute. NIH Publication No. 09-6366, August 2009
  2. Albuquerque EX, Pereira EFR, Alkondon M, Rogers SW (2008) Mammalian nicotinic acetylcholine receptors: from structure to function. Physiological Reviews, 89(1):73-120
  3. Gahring LC, Rogers SW (2006) Neuronal nicotinic acetylcholine receptor expression and function on non-neuronal cells. AAPS J, 7(4):E885-894

Hobby Studies on Dinosaur Neurobiology

  1. Rogers SW (2005) Reconstructing the behaviors of extinct species: An excursion into comparative paleoneurology. Amer J Med Gen, 134(4):349-356
  2. Rogers SW (1999) Allosaurus, crocodiles, and birds: evolutionary clues from spiral computed tomography of an endocast. Anat Rec, 257(5):162-173
  3. Rogers SW (1998) Exploring Dinosaur NeuroPaleobiology: Computed Tomography Scanning and Analysis of an Allosaurus fragilis Endocast. Neuron, 21(4):673-679

Scientific Advisor and Contributor to 2 BBC/Discovery Channel Science productions

  1. Walking with Dinosaurs: Allosaurus (2001)
  2. The Truth About Killer Dinosaurs (2006)

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Last Updated: 11/2/16