Chemical Biology/Medicinal Chemistry
Research Track
An inhibitor of hepatitis C virus replication causes a large structural change in a key region of the viral RNA. The inhibitor in yellow promotes transition from a 90 degree bent structure for the mRNA translation active conformation (green), toward an inactive, straight conformation (tan). Intermediate structures representing a hypothetical morphing trajectory between the two states are shown in orange.
Multinucleated Primary Mouse Fibroblast
Large Crosslinked Scaffold
GAGOSOME Model to Define GAG Biosynthesis
Role of Heparanome in Angiogenesis
Left: Endothelial cells with cell-surface bound HS chains form tubes in vitro.
Right: Endothelial cells fail to form tubes after loss of HS chains.
Click-Xylosides Stimulate Glycosaminoglycan Biosynthesis
Click on image for larger view.
We develop and apply chemical tools to understand biological problems and to propose biomedical solution. Our key research areas include:
- Chemical biology approaches to cancer and other diseases
- Total synthesis of biologically relevant target molecules
- Natural product discovery, biosynthesis and enzymology
- Structure-based drug design
- Computational approaches to drug discovery and analysis
- Formulation and delivery of drugs
- Nanotechnology as applied to medicine
- Development of new catalysts for the synthesis of active small molecules
- Metals in medicine and biology
- Enzymological synthesis and analysis of peptides and carbohydrates
Biological Chemistry Program Click Here
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