Ilya Zharov
assistant Professor of Chemistry
Diploma Chelyabinsk State University, Russia
Ph.D. University of Colorado, Boulder
Research
The general goal of our work is the preparation of functional molecules with interesting fundamental properties and useful applications. We use organic and inorganic synthesis, self-assembly and computational techniques to achieve this goal.
Boron Polyanion Dendrimers for Cancer Imaging and Therapy: The goal of this work is to develop water soluble, non-toxic, biodegradable polyester-based dendrons with multiple anionic boron clusters for imaging and therapy of cancers. In order to selectively target tumor cells, a ligand or a monoclonal antibody will be connected via the carboxylic acid at the focal point of the dendron.
Nanopores as Ion Channel Mimics: The goal of this project is to modify the inner walls of 5-50 nm wide nanopores made in a thin inorganic support, with organic molecules whose size and shape are sensitive to external stimuli, such as pH, solvent polarity, light, etc. Inorganic supports being presently investigated are glass, silica, and silicon nitride.
References
1. Mollard A, Zharov I (2006) Tricarboranyl Pentaerythritol-Based Building Block. Inorg. Chem. 45:10172-9
2. Wang G, Bohaty AK, Zharov I, White HS (2006) Photon-Gated Transport at the Glass Nanopore Electrode. J. Am. Chem. Soc. 128:13553-13558
3. Galie KM, Mollard A, Zharov I (2006) Polyester-Based Carborane-Containing Dendrons. Inorg. Chem. 45:7815-7820
4. Schepelina O, Zharov I (2006) Polymer-Modified Opal Nanopores. Langmuir 22:10523-7
5. Cichelli J, Zharov I (2006) Chiral Selectivity in Surface-Modified Nanoporous Opal Films. J. Am. Chem. Soc. 128:8130-8131
6. Bohaty AK, Zharov I (2006) Suspended Self-Assembled Opal Membranes. Langmuir 22:5533-5536
7. Newton MR, Bohaty AK, Zhang Y, White HS, Zharov I (2006) pH and Ionic Strength Controlled Permselectivity in Amine Modified Nanoporous Opal Films. Langmuir 22:4429-4432 (journal cover)
8. Newton MR, Bohaty AK, White HS, Zharov I (2005) Chemically Modified Opals as Thin Permselective Nanoporous Membranes. J. Am. Chem. Soc. 127:7268-9
9. Zharov I, Weng T-C, Orendt AM, Barich DH, Penner-Hahn J, Grant DM, Havlas Z, Michl J (2004) Metal Cation-Methyl Interactions in CB11Me12- Salts of Me3Ge+, Me3Sn+, and Me3Pb+. J. Am. Chem. Soc. 126:12033
10. Zimmerman SC, Zharov I, Wendland MS, Rakow NA, Suslik KS (2003) Molecular Imprinting Inside Dendrimers. J. Am. Chem. Soc. 125:13504
11. Zimmerman SC, Wendland MS, Rakow NA, Zharov I, Suslik KS (2002) Synthetic Hosts by Monomolecular Imprinting Inside Dendrimers. Nature 418:399
12. Rotkin SV, Zharov I (2002) Nanotube Light-Controlled Electronic Switch. Int. J. Nanosci. 1:347
13. Zharov I, Michl J, Sherwood MH, Sooriyakamarun R, Larson CE, DiPietro RA, Breyta G, Wallraff GM (2002) Mechanistic Studies of the Acidolysis Reactions Occurring in Silicon-Containing Bilayer Photoresists. Chem. Mater. 14:656
14. Michl J, King BT, Zharov I (2001) Alkylated Carborane Anions: Tools for Organic and Inorganic Chemists. Chem. Innov. 12:23
15. Zharov I, King BT, Havlas Z, Pardi A, Michl J (2000) Crystal Structure of n-Bu3Sn+ CB11Me12-. J. Am. Chem. Soc. 122:10253
